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KMID : 0350519930460010267
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Journal of Catholic Medical College
1993 Volume.46 No. 1 p.267 ~ p.275
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A Comparative analysis on Clinical and Nerve Conduction Findings in Patients with Uremic Neuropathy after Kidney Transplantation
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어강 황경태
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Abstract
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This study was designed to investigate the extent of impaired nerve conduction, the most sensitive indicator for detection of nerve conduction parameters, and the changes of clinical and nerve conduction findings in patients with uremic neuropathy before and after kidney transplantation.,
The present study included 21 uremic patients(15 males, 6 females), whose clinical and electrophysiological studies were serially followed up 2, 4 and 6 months after kidney transplantation at Kangnam St. Mary´s hospital from November, 1990 to February,
1991. Forty-four age-matched control subjects(male 21, female 23) ware also studied.
@ES The results were as follows :
@EN 1. The incidence of peripheral neuropathy was 76.2% of the uremic patients in this study.
2. In the nerve conduction studies of the uremic patients with peripheral neuropathy before kidney transplantation, the conduction velocities of peroneal and median motor nerves, the distal latency of median motor nerve, the distal latencies of median
and sural sensory nerves, and the amplitude of action potential of sural sensory nerve were significantly impaired, as compared with those of control group
3. Of all abnormal nerve conduction parameters, the distal latency of sensory sural nerve was the most sensitive indicator for detection of early uremic neuropathy(P<0.033).
4. The correlation between the distal latency of sensory sural nerve and the two point discrimination was found to be statistically significant in patients with uremic neuropathy(P<0.000, r<0.723). However, there was no statistical difference between the distal latency of sensory sural nerve and the values of either BUN or serum creatinine.
5. The values of BUN and serum creatinine 2 months after kidney transplantation were markedly decreased, as compared with those of before transplantation(P<0.000, P<0.000). And seral changes of BUN 4 and 6 months after transplantation were also
statistically significant(P<0.040, P<0.025), but those of serum creatinine were not.
6. In the improvement of conduction parameters after kidney transplantation, the earliest recovery was observed in the conduction velocity of moter peroneal nerve at 2 months(P<0.023), to be followed by the distal latency of sensory sural nerve 4 months after transplantation(P<0.038). In most patients with uremic neuropathy the nerve conduction parameters were improved to the mean values of control group 6 months after a sccessful kidney transplantation.
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